Dangan Ronpa: Trigger Happy HavocEdit
At the start of the events of the first Dangan Ronpa game, Sakura, as well as fourteen others, found themselves in Hope's Peak, with its doors and windows to the outside world completely sealed shut. An odd robot bear named Monokuma explains that they're all essentially supposed to live within the academy for the rest of their lives, and if anyone wants out, they have to murder a person in the school and get away with it at the School Trial, kickstarting the "School Life of Mutual Killing".
However, it was eventually revealed that Sakura was blackmailed by Monokuma to be a mole for him early into the game, in exchange for the safety of her family and her dojo. She was supposed to start a killing incident should the survivors stabilize amongst themselves, but she was not needed to do so as Leon stabbed Sayaka "out of self-defense", Mondo bludgeoned Chihiro with a dumbbell in a fit of uncontrollable rage, and Celestia masterminding the murders of Kiyotaka and Hifumi.
At this point, Sakura has had enough with deceiving her friends anymore, and she decided to confront Monokuma and crush his psychotic mind games once and for all, as Makoto witnessed after waking up from being knocked out.
Before Sakura can properly confess to the remaining survivors, however, Monokuma beat her to the punch by revealing her to be his mole, which lead to an incident caused by animosity between the aloof Byakuya, lovestruck Toko, and defensive Aoi, who tried to protect Sakura from further slander. Following this, Sakura figured that the only way to do what Monokuma instructed without harming any of her friends was to commit suicide.
To that end, Sakura wrote a farewell letter penned in old calligraphy, and busted the door to the Principal's Office before setting up a rendezvous at the Rec Room with Yasuhiro, Toko, and Byakuya. Byakuya didn't come on the suspicion that Sakura might try to kill him. Yasuhiro and Toko did arrive to the Rec Room, but by misinterpreting her message, or being forced into action, both of them struck Sakura on the head with Monokuma bottles.
Aoi, while initially shocked by her injury, having tried to dissuade her to meet up with those three, was asked by Sakura to make her a protein shake at the Chemistry Lab. Once that was done and Aoi left the Rec Room, Sakura barricaded the room and downed the protein shake, which was actually poison by switching the contents in the Chemistry Lab, vomiting blood as the poison took effect.
Despite the pain, Sakura died with a smile on her face, confident that her friends will not kill each other anymore.
Dangan Ronpa 2: Goodbye Despair Edit
Sakura makes a cameo in the fourth chapter as a statue in the Strawberry/Grape tower.
Dangan Ronpa 3: The End of Hope's Peak Edit
Side:Future Episode 11: All Good Things Edit
While Makoto was being brainwashed by the video in the Future Foundation building monitors, he hallucinates seeing all of his deceased friends, including Sakura, saying that it's all his fault everyone's dead.
Side:Despair Episode 11: Goodbye, Hope's Peak Academy Edit
As the world gets plunged into despair, the 78th class barricaded themselves in the old Hope's Peak building from the first game. Sakura can be seen screwing in the bolts on the metal plates with her bare hands.